WebBackground. Ferritin (FTH) is a ubiquitous and highly conserved protein which plays a major role in iron homeostasis by sequestering and storing iron in a non-toxic and bioavailable form (1). The assembled ferritin molecule, often referred to as a nanocage, can store up to 4,500 atoms of iron (2,3). It forms a holoenzyme of ~450 kDa, consisting ... WebApr 20, 2024 · Up to now, FTH1 is generally considered to have antioxidant properties that could protect cells from reactive oxygen species (ROS) due to its ferroxidase activity which could catalyse the conversion of Fe 2+ into Fe 3+. 17, 20 Meanwhile, NF‐κB‐mediated FTH1 upregulation is thought to protect cells from apoptosis. 35, 40 However, our ...
Frontiers Ferroptosis Driver SOCS1 and Suppressor FTH1 Independently ...
WebDec 29, 2024 · The expression level of FTH1 in various tumors. A The expression of FTH1 in various cancer types was summarized by the SangerBox tool.B Heatmap showed the relationship of overall survival and FTH1 in varieties of cancers (GEPIA database).C Transcriptional expression profiles of FTH1 in multiple cancer types (Oncomine … WebView mouse Fth1 Chr19:9957962-9962462 with: phenotypes, sequences, polymorphisms, proteins, references, function, expression futuristic fashion functional
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The quality and quantity of extracted RNA was measured using on-chip electrophoresis utilizing the Agilent RNA 6000 Nano Kit (Agilent Technologies, CA, USA) and Agilent 2100 Bioanalyzer (Agilent Technologies) as per the manufacturer’s instructions. Samples exhibiting an RNA Integrity Number (RIN) > … See more Decitabine and 5-Azacytidine small molecule inhibitors were purchased from Selleckchem (Houston, TX, USA). Inhibitors were dissolved in dimethyl sulfoxide (DMSO) (Sigma Aldrich, St.Louis, MO, USA) … See more Forty-eight hours post inhibitor treatment (2.0 μM), total RNA was isolated from treated and control TNBC cells using total RNA purification kit … See more Human TNBC (MDA-MB-231 and BT-549) cell lines were cultured in Dulbecco's Modified Eagle Medium (DMEM) supplemented with 10% fetal bovine serum (FBS) and 1% penicillin/streptomycin … See more Total RNA samples with a RIN higher than 9 were used as input for the library preparation using TruSeq Stranded Total RNA Library Prep … See more WebSep 22, 2024 · Overexpression of ferritin heavy chain (FTH1) often associates with good prognosis in breast cancer (BCa), particularly in the triple-negative subtype (triple-negative breast cancer).However, the mechanism by which FTH1 exerts its possible tumor suppressor effects in BCa is not known. Here, we examined the bearing of FTH1 … http://images.novusbio.com/design/PS_NFKBSignaling_27113.pdf glaceau smartwater stock price